CAR-T therapy plays a key role in cancer immunotherapy and belongs to adoptive T cell transfer (ACT). At the beginning of June, the annual meeting of the American Society of Clinical Oncology (ASCO) was held in which CAR T therapy was still a hot topic. And Celgene and Bluebird have released the latest cell therapy data, showing once again the potential of this new cancer immunotherapy.
In 2017, the first two CAR-T cell therapies approved by FDA—Kymriah of Novartis and Yescarta of Kite
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Pharma (acquired by Gilead) were used to treat acute lymphoblastic leukemia and specific types of non-Hodgkin’s lymphoma, respectively, contributing to the rapid development of CAR-T therapy.
CAR-T therapy is very different from traditional drugs. First, the therapy requires the isolation of T cells from the patient's body. The T cell is modified in vitro using a chimeric antigen receptor (CAR) to specifically recognize cancer cells, and then the transformed T cells are expanded and returned to the patient's body. https://www.creative-biolabs.com/car-t/cellrapeutics-chimeric-antigen-receptor-car-technology.htm